These observations are in contrast to previous findings in the same Nrf2-GFP-HepG2 reporter model exposed to DEM or tert -butylhydroquinone, which indicate a lower Nrf2 response toward repeated treatments (Bischoff et al
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dosing at 8 hours works but sacrifices the upper range of synergy
Intranasal delivery: promising, but formulation dependent Intranasal delivery is attractive because its noninvasive and can offer faster absorption for certain molecules, but it still struggles with mucosal barriers, clearance, and dose limitations
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